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Precose regimen was superior to lower doses, but there were no statistically significant differences from 50 to 200 mg t. Low serum calcium and low plasma vitamin B6 levels were associated with Precose therapy but are thought to be either spurious or of no clinical significance. It is recommended that serum transaminase levels be checked every 3 months during the first year of treatment with Precose and periodically thereafter. However, the peak plasma level of metformin was reduced by approximately 20% when taking Precose due to a slight delay in the absorption of metformin. As a consequence of plasma glucose reduction, Precose reduces levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus. placebo-controlled trials, the incidences of abdominal pain, diarrhea, and flatulence were 19%, 31%, and 74% respectively in 1255 patients treated with Precose 50-300 mg t.

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